Manu National Park covers an area of 1,716,295.22 hectares (17,162.95 km2) which comprises mountainous areas (traversed by creeks and valleys) with elevations close to 4000 m above sea level and a portion of the Amazon Basin plains.
The national park is divided in the following areas: the restricted use zone (with pristine forests and native communities, access is granted to researchers only); the reserved zone (for recreation and research); the recuperation zone (for the recovery of disturbed areas) and the cultural zone (for human settlement and most activities including nature tourism ).
Climate in the park is highly variable, rainy and depends on the elevation. The southern section (mountainous) has an annual precipitation between 1500–2000 mm; while in the middle section it is between 3000–3500 mm and in the northwestern section the annual precipitation reaches 8000 mm or more. The less rainy season is from May to September, accompanied by lower temperatures.